Connes Philippe

Date de dernière mise à jour : le 25 août 2015

Fonction : Professeur des Universités, Membre de l'Institut Universitaire de France

Grade : Professeur des Universités

Responsabilités : Sociétés savantes: - Membre du Conseil d'Administration de la Société Internationale d'Hémorhéologie Clinique (ISCH) - Membre du Conseil d'Administration de la Société Européenne d'Hémorhéologie Clinique et de Microcirculation (ESCHM) - Membre du Conseil d'Administration de l'Association des Chercheurs en Activités Physiques et Sportives (ACAPS) Editorial Board Member: - British Journal of Sports Medicine (IPHP Section), IF: 4.17 - Clinical Hemorheology and Microcirculation, IF: 2.22 - Plos One, IF: 3.53 - BMC Hematology (Non malignant hematological diseases Section), IF: not yet

Thèmes de recherche : 1) Physiopathologie de la drépanocytose : biomarqueurs de sévérité et modulateurs hémorhéologiques, vasculaires et physiologiques ; 2) Exercice et Drépanocytose

Mots clés : Drépanocytose, hémorhéologie, microcirculation, fonction vasculaire, Exercice

Réseaux sociaux

Researchgate

Ouvrages

L1. Exercise Physiology: from a cellular approach to an integrative approach (Editors: P Connes, O Hue, S Perrey – Edition : IOS Press), 692 p, 2010. ISBN:  978-1-60750-496-2 http://www.iospress.nl/loadtop/load.php?isbn=9781607504962

Articles internationaux

P1. Caillaud C, Connes P, Bouix D and Mercier J. Does haemorheology explain the paradox of hypoxemia during exercise in elite athletes or thoroughbred horses? Clin Hemorheol Microcirc 26: 175-181, 2002. IF: 3.398 P2. Audran M, Connes P and Varlet-Marie E. Transport sanguin de l’oxygène et dopage. Bull Acad Natle Méd 187: 1669-1683, 2003. IF: 0.25 P3. Connes P, Perrey S, Varray A, Prefaut C and Caillaud C. Faster oxygen uptake kinetics at the onset of submaximal cycling exercise following 4 weeks recombinant human erythropoietin (r-HuEPO) treatment. Pflugers Arch 447: 231-238, 2003. IF: 4.463 P4. Connes P, Bouix D, Py G, Caillaud C, Kippelen P, Brun JF, Varray A, Prefaut C and Mercier J. Does exercise-induced hypoxemia modify lactate influx into erythrocytes and hemorheological parameters in athletes? J Appl Physiol 97: 1053-1058, 2004. IF: 3.753 P5. Connes P, Bouix D, Durand F, Kippelen P, Mercier J, Prefaut C, Brun JF and Caillaud C. Is hemoglobin desaturation related to blood viscosity in athletes during exercise? Int J Sports Med 25: 569-574, 2004. IF: 2.433 P6. Connes P, Caillaud C, Simar D, Villard S, Sicart MT and Audran M. Strengths and weaknesses of established indirect models to detect recombinant human erythropoietin abuse on blood samples collected 48-hr post administration. Haematologica 89: 891-892, 2004. IF: 6.424 P7. Connes P, Bouix D, Py G, Prefaut C, Mercier J, Brun JF and Caillaud C. Opposite effects of in vitro lactate on erythrocyte deformability in athletes and untrained subjects. Clin Hemorheol Microcirc 31: 311-318, 2004. IF: 3.398 P8. Connes P, Caillaud C, Mercier J, Bouix D and Casties JF. Injections of recombinant human erythropoietin increases lactate influx into erythrocytes. J Appl Physiol 97: 326-332, 2004. IF: 3.753 P9. Racinais S, Connes P, Bishop D, Blonc S and Hue O. Morning versus evening power output and repeated-sprint ability. Chronobiol Int 22: 1029-1039, 2005. IF: 4.028 P10. Monchanin G, Connes P, Wouassi D, Francina A, Djoda B, Banga PE, Owona FX, Thiriet P, Massarelli R and Martin C. Hemorheology, Sickle Cell Trait, and alpha-Thalassemia in Athletes: Effects of Exercise. Med Sci Sports Exerc 37: 1086-1092, 2005. IF: 4.431 P11. Kippelen P, Caillaud C, Robert E, Connes P, Godard P and Prefaut C. Effect of endurance training on lung function: a one year study. Br J Sports Med 39: 617-621, 2005. IF: 4.144 P12. Connes P, Sara F, Hardy-Dessources MD, Etienne-Julan M and Hue O. Does Higher Red Blood Cell (RBC) Lactate Transporter Activity Explain Impaired RBC Deformability in Sickle Cell Trait? Jpn J Physiol 55: 385-387, 2005. IF: 1.606 P13. Sara F, Connes P, Hue O, Montout-Hedreville M, Etienne-Julan M and Hardy-Dessources MD. Faster Lactate Transport across Red Blood Cell Membrane in Sickle Cell Trait Carriers. J Appl Physiol 100: 437-442, 2006. IF: 3.753 P14. Sara F, Hardy-Dessources MD, Marlin L, Connes P and Hue O. Lactate distribution in the blood compartments of sickle cell trait carriers during incremental exercise and recovery. Int J Sports Med 27: 436-443, 2006. IF: 2.433 P15.Ninot G, Connes P and Caillaud C. Effects of recombinant human erythropoietin injections on physical self in endurance athletes. J Sports Sci 24: 383-391, 2006. IF: 1.931 P16. Connes P, Sara F, Hardy-Dessources MD, Marlin L, Etienne F, Larifla L, Saint-Martin C and Hue O. Effects of short supramaximal exercise on hemorheology in sickle cell trait carriers. Eur J Appl Physiol 97: 143-150, 2006. IF: 2.147 P17. Connes P, Sara F and Hue O. Point:Counterpoint: Lactic acid accumulation is an advantage/disadvantage during muscle activity. J Appl Physiol 101: 1269, 2006. IF : 3.753 P18. Connes P, Yalcin O, Baskurt O, Brun JF and Hardeman M. In health and in a normoxic environment, VO2 max is/is not limited primarily by cardiac output and locomotor muscle blood flow. J Appl Physiol 100: 2099, 2006. IF: 3.753 P19. Connes P, Monchanin G, Perrey S, Wouassi D, Atchou G, Forsuh A, Debaud J, Djoda B, Owona FX, Francina A, Banga PE, Massarelli R, Thiriet P and Martin C. Oxygen Uptake Kinetics During Heavy Submaximal Exercise: Effect of Sickle Cell Trait With or Without Alpha-Thalassemia. Int J Sports Med 27: 517-525, 2006. IF: 2.433 P20. Connes P, Racinais S, Sara F, Marlin L, Hertogh C, Saint-Martin C, Etienne-Julan M and Hue O. Does the pattern of repeated sprint ability differ between sickle cell trait carriers and healthy subjects? Int J Sports Med 27: 937-942, 2006. IF: 2.433 P21. Connes P, Martin C, Barthelemy JC, Monchanin G, Atchou G, Forsuh A, Massarelli R, Wouassi D, Thiriet P and Pichot V. Nocturnal autonomic nervous system activity impairment in sickle cell trait carriers. Clin Physiol Funct Imaging 26: 87-91, 2006. IF: 1.213 P22. Tripette J, Hardy-Dessources MD, Sara F, Montout-Hedreville M, Saint-Martin C, Hue O and Connes P. Does prolonged and heavy exercise impair blood rheology in sickle cell trait carriers? Clin J Sports Med, 17: 465-470, 2007. IF: 2.119 P23. Marlin L, Sara F, Antoine-Jonville S, Connes P, Etienne-Julan M and Hue O. Ventilatory and Lactic Thresholds during Exercise in Subjects with Sickle Cell Trait. Int J Sports Med, 28: 916-920, 2007. IF: 2.433 P24. Connes P, Caillaud C, Py G, Mercier J, Hue O and Brun JF. Maximal exercise and lactate do not change red blood cell aggregation in well trained athletes. Clin Hemorheol Microcirc, 36: 319-326, 2007. IF: 3.398 P25. Monchanin G, Serpero LD, Connes P, Tripette J, Wouassi D, Bezin L, Francina A, Ngongang J, de la Pena M, Massarelli R, Gozal D, Thiriet P and Martin C. Effects of a progressive and maximal exercise on plasma levels of adhesion molecules in athletes with sickle cell trait with or without alpha-thalassemia. J Appl Physiol 102: 169-173, 2007. IF: 3.753 P26. Connes P, Hardy-Dessources MD and Hue O. Counterpoint: Sickle cell trait should not be considered asymptomatic and as a benign condition during physical activity. J Appl Physiol, 103: 2138-2140, 2007. IF: 3.753 P27. Connes P, Reid H, Hardy-Dessources MD, Morrison E and Hue O. Advantages and disadvantages of sickle cell trait during exercise. Sports Med, 38: 931-946, 2008. IF: 5.155 P28. Connes P and Boisseau MR. [News in hemorheology]. J Mal Vasc, I33: 169-172, 2008. IF: 0.543 P29. Monchanin G, Serpero Laura D, Connes P, Tripette J, Wouassi D, Francina A, Massarelli R, Gozal D, Thiriet P and Martin C. Plasma levels of adhesion molecules ICAM-1 and VCAM-1 in athletes with sickle cell trait with or without alpha-thalassemia during endurance exercise and recovery. Clin Hemorheol Microcirc, 40: 89-97, 2008. IF: 3.398 P30. Marlin L, Connes P, Antoine-Jonville S, Tripette J, Montout-Hedreville M, Sara F, Sanouiller A, Etienne-Julan M and Hue O. Cardiorespiratory responses during three repeated incremental exercise tests in sickle cell trait carriers. Eur J Appl Physiol, 102: 181-187, 2008. IF: 2.147 P31. Connes P, Hue O, Hardy-Dessources MD, Boucher JH, Pichot V and Barthelemy JC. Hemorheology and heart rate variability: is there a relationship? Clin Hemorheol Microcirc, 38: 257-265, 2008. IF: 3.398 P32. Connes P, Tripette J, Chalabi T, Beltan E, Etienne-Julan M, Chout R, Hue O and Hardy-Dessources MD. Effects of strenuous exercise on blood coagulation activity in sickle cell trait carriers. Clin Hemorheol Microcirc, 38: 13-21, 2008. IF: 3.398 P33. Hedreville M, Barthelemy JC, Tripette J, Roche F, Hardy-Dessources MD, Pichot V, Hue O and Connes P.Effects of strenuous exercice on autonomic nervous system activity in sickle cell trait carriers. Auton Neurosci, 143: 68-72, 2008. IF: 1.858 P34. Connes P, Hue O, Tripette J and Hardy-Dessources MD. Blood rheology abnormalities and vascular cell adhesions mechanisms in sickle cell trait carriers during exercise. Clin Hemorheol Microcirc, 39: 179-184, 2008. IF: 3.398 P35. Connes P and Barthelemy JC. Comment on "Abnormal autonomic cardiac response to transient hypoxia in sickle cell anemia". Phyiol Measur, 29: L1-L2, 2008. IF: 1.667 P36. Boucher JH and Connes P. Hemorheopathy in exercising horses. Clin Hemorheol Microcirc, 40: 73-75, 2008.  IF: 3.398 P37. Connes P, Tripette J, Mukisi-Mukasa M, Baskurt OK, Toth K, Meiselman HJ, Hue O and Antoine-Jonville S. Relationships between hemodynamic, hemorheologic and metabolic responses during exercise. Biorheology, 46: 133-143, 2009. IF: 1.93 P38. Uyuklu M, Cengiz M, Ulker P, Hever T, Tripette J, Connes P, Nemeth N, Meiselman HJ and Baskurt OK. Effect of storage duration and temperature after blood sampling on red blood cell deformability and aggregation parameters. Clin Hemorheol Microcirc, 41: 269-278, 2009. IF: 3.398 P39. Connes P, Uyuklu M, Tripette J, Boucher JH, Beltan E, Chalabi T, Yalcin O, Chout R, Hue O, Hardy-Dessources MD and Baskurt O.Sampling time after tourniquet removal affects erythrocyte deformability and aggregation  measurements. Clin Hemorheol Microcirc, 41: 9-15, 2009. IF: 3.398 P40. Tripette J, Alexy T, Hardy-Dessources MD, Mougenel D, Beltan E, Chalabi T, Chout R, Etienne-Julan M, Hue O, Meiselman HJ and Connes P. Red blood cell aggregation, aggregate strength and oxygen transport potential of blood are abnormal in both homozygous sickle cell anemia and sickle-hemoglobin C disease. Haematologica, 94: 1060-1065, 2009. IF: 6.424 P41. Connes P, Nemeth N, Meiselman HJ and Baskurt OK. Effect of tourniquet application during blood sampling on RBC deformability and aggregation: is it better to keep it on? Clin Hemorheol Microcirc, 42: 297-302, 2009. IF: 3.398 P42. Inamo J, Connes P, Barthelemy JC, Dan V, Coates TD and Loko J. Pulmonary hypertension does not affect the autonomic nervous system dysfunction of sickle cell disease. Am J Hematol, 84: 311-312, 2009. IF: 4.671 P43. Connes P. Elevated blood viscosity during exercise: what are the consequences? Clin Hemorheol Microcirc, 42: 303-304, 2009. IF: 3.398 P44. Hedreville M, Connes P, Romana M, Magnaval G, David T, Hardy-Dessources MD, Belloy MS, Etienne-Julan M and Hue O.Central retinal vein occlusion followed by neovascular glaucoma in a sickle cell trait carrier after a prolonged cycling race: a case study. Med Sci Sports Exerc, 41: 14-18, 2009. IF: 4.431 P45. Hue O, Connes P, Romana M, Etienne-Julan M and Hardy-Dessources MD. Sickle cell trait carriers in sports: a medical consideration in Guadeloupe. Scand J Med Sci Sports, 19: 603-605, 2009. IF: 2.867 P46. Baskurt OK, Boynard M, Cokelet GC, Connes P, Cooke BM, Forconi S, Liao F, Hardeman MR, Jung F, Meiselman HJ, Nash G, Nemeth N, Neu B, Sandhagen B, Shin S, Thurston G and Wautier JL. New guidelines for hemorheological laboratory techniques. Clin Hemorheol Microcirc 42: 75-97, 2009. IF: 3.398 P47. Brun JF, Varlet-Marie E, Connes P and Aloulou I. Hemorheological alterations related to training and overtraining. Biorheology, 47: 95-115, 2010. IF: 1.93 P48. Connes P and Boucher JH. Echinocytosis in athletes with exercise-induced hypoxemia. Clin Hemorheol Microcirc, 44: 107-114, 2010. IF: 3.398 P49. Tripette J, Connes P, Hedreville M, Etienne-Julan M, Marlin L, Hue O and Hardy-Dessources MD. Patterns of exercise related inflammatory response in sickle cell trait carriers. Brit J Sports Med, 44: 232-237, 2010. IF: 4.144 P50. Tripette J, Loko G, Samb A, Doubi BG, Sewade E, Seck D, Hue O, Romana M, Diop S, Diaw M, Brudey K, Bogui P, Cisse F, Hardy-Dessources MD and Connes P. Effects of hydration and dehydration on blood rheology in sickle cell trait carriers during exercise. Am J Physiol (Heart Circ Physiol) 299: H908-914, 2010. IF: 3.708 P51. Nebor D, Broquere C, Brudey K, Mougenel D, Tarer V, Connes P, Elion J and Romana M. The presence of alpha-thalassemia decreases the occurence and increases the age-at-onset of albuminuria in sickle cell anemia patients. Blood Cells Mol Dis 45: 154-158, 2010. IF: 2.351 P52. Alexy T, Sangkatumvong S, Connes P, Pais E, Tripette J, Barthelemy JC, Fisher TC, Meiselman HJ, Khoo MC and Coates TD. Sickle cell disease: Selected aspects of pathophysiology, autonomic nervous system function and rheological considerations in transfusion therapy. Clin Hemorheol Microcirc, 44: 155-166, 2010. IF: 3.398 P53. Grantham J, Cheung S, Connes P, Febbraio M, Gaoua N, Gonzalez-Alonso J, Hue O, Johnson J, Maughan R, Meeusen R, Nybo L, Racinais S, Saltin B, Shirreffs S, Dvorak J. Current knowledge on playing Football in hot environments. Scand J Med Sci Sports 20 Suppl 3: 161-167, 2010. IF: 2.867 P54. Connes P, Suhr F, Martin C, Shin S, Aufradet E, Sunoo S, Klara B, Raynaud de Mauverger E, Romana M, Messonnier L, Kang J, Varlet-Marie E, Feasson L, Hardy-Dessources MD, Bloch W and Brun JF. New fundamental and applied mechanisms in exercise hemoreology. Clin Hemorheol Microcirc, 45: 131-141, 2010. IF: 3.398 P55. Connes P. Hemorheology and exercise: effects of warm environment and potential consequences for sickle cell trait carriers. Scand J Med Sci Sport, 20 Suppl 3: 48-52, 2010. IF: 2.867 P56. Tripette J, Connes P, Beltan E, Chalabi T, Marlin L, Chout R, Baskurt O, Hue O and Hardy-Dessources MD. Red blood cell deformability and aggregation, cell adhesions molecules, oxidative stress and nitric oxide markers in exercising sickle cell trait carriers. Clin Hemorheol Microcirc, 45: 39-52, 2010. IF: 3.398 P57. Ahmadizad S, Moradi A, Nikookheslat S, Ebrahimi H, Rahbaran A and Connes P. Effects of age on hemorheological responses to acute endurance exercise. Clin Hemorheol Microcirc 49: 165-174, 2011. IF: 3.398 P58. Balayssac-Siransy EA, Connes P, Tuo N, Danho C, Diaw M, Sanogo I, Hardy-Dessources MD, Samb A, Ballas SK and Bogui P. Mild hemorheological changes induced by a moderate endurance exercise in patients with sickle cell anemia. Br J Haematol 154: 398-407, 2011. IF: 4.941 P59. Tripette J, Hardy-Dessources MD, Beltan E, Sanouiller A, Bangou J, Chalabi T, Chout R, Hedreville M, Broquere C, Nebor D, Dotzis G, Hue O and Connes P. Endurance running trial in tropical environment: a blood rheological study. Clin Hemorheol Microcirc 47: 261-268, 2011. IF: 3.398 P60. Chaar V, Romana M, Tripette J, Broquere C, Huisse MG, Hue O, Hardy-Dessources MD and Connes P. Effects of intense exercise on blood cell-derived microparticles. Clin Hemorheol Microcirc 47: 15-25, 2011. IF: 3.398 P61. Beltan E, Chalabi T, Tripette J, Chout R and Connes P. Coagulation responses after a submaximal exercise in sickle cell trait carriers. Thromb Research 127: 167-169, 2011. IF: 2.44 P62. Nebor D, Bowers A, Hardy-Dessources MD, Knight-Madden JM, Romana M, Reid H, Barthelemy JC, Cumming V, Hue O, Elion J, Reid M and Connes P. Frequency of painful crises in sickle cell anemia and its relationships with the sympatho-vagal balance, blood viscosity and inflammation. Haematologica 96: 1589-1594, 2011. IF: 6.424 P63. Simmonds MJ, Tripette J, Sabapathy S, Marshall-Gradisnik SM and Connes P. Cardiovascular dynamics during exercise are related to blood rheology. Clin Hemorheol Microcirc 49: 231-241, 2011. IF: 3.398 P64. Connes P, Machado R, Hue O and Reid H. Exercise limitation, exercise testing and exercise recommendations in sickle cell anemia. Clin Hemorheol Microcirc 49: 151-163, 2011. IF: 3.398 P65. Connes P. Altered autonomic nervous system function in sickle cell disease. Am J Respir Crit Care Med 184: 398-400, 2011. IF: 11.08 P66. O'Connor F, Bergeron MF, Cantrell J, Connes P, Harmon KG, Ivey E, Kark J, Klossner D, Lisman P, Meyers BK, O'Brien K, Ohene-Frempong K, Thompson AA, Whitehead J, Deuster PA. American College of Sports Medicine and Consortium for Health and Military Performance Summit on Sickle Cell Trait: Mitigating Risks for Warfighters and Athletes. Med Sci Sports Exerc 44: 2045-2056, 2012. IF: 4.431 P67. Connes P, Pichon A, Hardy-Dessources MD, Waltz X, Lamarre Y, Simmonds MJ, Tripette J. Blood viscosity and hemodynamics during exercise. Clin Hemorheol Microcirc 51: 101-109, 2012. IF: 3.398 P68. Lemonne N, Connes P, Romana M, Vent-Schmidt J, Bourhis V, Lamarre Y and Etienne-Julan M. Increased blood viscosity and red blood cell aggregation in a patient with sickle cell anemia and smoldering myeloma. Am J Hematol87: E129, 2012. IF: 4.671 P69. Messonnier L, Samb A, Tripette J, Doubi BG, Loko G, Sall ND, Feasson L, Hue O, Lamothe S, Bogui P, Connes P. Moderate endurance exercise is not a risk for rhabdomyolysis or renal failure in sickle cell trait carriers. Clin Hemorheol Microcirc 51: 193-202, 2012. IF: 3.398 P70. Lamarre Y, Petres S, Hardy-Dessources MD, Sinnapah S, Romana M, Lemonne N, Laurance S, Gysin J and Connes P. Abnormal flow adhesion of sickle red blood cells to human placental trophoblast extracellular matrix. Clin Hemorheol Microcirc 51: 229-234, 2012. IF: 3.398 P71. Waltz X, Hedreville M, Sinnapah S, Lamarre Y, Soter V, Lemonne N, Etienne-Julan M, Beltan E, Chalabi T, Chout R, Hue O, Mougenel D, Hardy-Dessources MD, Connes P. Delayed beneficial effect of acute exercise on red blood cell aggregate strength in patients with sickle cell anemia. Clin Hemorheol Microcirc 52: 15-26, 2012. IF: 3.398 P72. Pichon A, Connes P, Quidu P, Marchant D, Brunet J, Levy BI, Vilar J, Safeukui I, Cymbalista F, Maignan M, Richalet JP, Favret F. Acetazolamide and chronic hypoxia: effects on hemorheology and pulmonary hemodynamics. Eur Resp J 40: 1401-1409, 2012. IF: 5.895 P73. Lamarre Y, Romana M, Waltz X, Lalanne-Mistrih ML, Tressieres B, Divialle-Doumdo L, Hardy-Dessources MD, Vent-Schmidt J, Petras M, Broquere C, Maillard F, Tarer V, Etienne-Julan M, Connes P. Hemorheological risk factors of acute chest syndrome and painful vaso-occlusive crisis in sickle cell disease. Haematologica 97: 1641-1647, 2012. IF: 6.424 P74. Waltz X, Pichon A, Mougenel D, Lemonne N, Lalanne-Mistrih ML, Sinnapah S, Tarer V, Tressieres B, Lamarre Y, Etienne-Julan M, Hue O, Hardy-Dessources MD and Connes P. Hemorheological alterations, decreased cerebral microvascular oxygenation and cerebral vasomotion compensation in sickle cell patients. Am J Hematol87: 1070-1073, 2012. IF: 4.671 P75. Waltz X, Pichon A, Lemonne N, Mougenel D, Lalanne-Mistrih ML, Lamarre Y, Tarer V, Tressieres B, Etienne-Julan M, Hardy-Dessources MD, Hue O and Connes P. Normal muscle oxygen consumption and fatigability in sickle cell patients despite reduced microvascular oxygenation and hemorheological abnormalities. PLoS One 7: e52471, 2012. IF: 4.092 P76. Chalencon S, Busso T, Lacour JR, Garet M, Pichot V, Connes P, Gabel CP, Roche F and Barthelemy JC. A Model for the Training Effects in Swimming demonstrates a Strong Relationship between Parasympathetic Activity, Performance and Index of Fatigue. Plos One 7: e52636, 2012. IF: 4.092 P77. Knight-Madden JM, Connes P, Bowers A, Nebor D, Hardy-Dessources MD, Romana M, Reid H, Pichon AP, Barthelemy JC, Cumming VB, Elion J, Reid M. Relationship between Acute Chest Syndrome and the sympatho-vagal balance in adults with hemoglobin SS disease; a case control study. Clin Hemorheol Microcirc 53: 231-238, 2013. IF: 3.398 P78. Lamarre Y, Bourgeaux V, Pichon A, Hardeman M, Campion Y, Hardeman-Zijp M, Martin C, Richalet JP, Bernaudin F, Driss F, Godfrin Y, Connes P. Effect of Inositol hexaphosphate-loaded red blood cells on the rheology of sickle cell patients. Transfusion 53: 627-636, 2013. IF: 3.217 P79. Franco M, Collec E*, Connes P*, Van Den Akker E, Billette de Vilmeur T, Belmatoug N, Von Lindem M, Ameziane N, Hermine O, Colin Y, Le Van Kim C and Mignot C. Gaucher disease: abnormal properties of red blood cells suggest a prominent role in vascular occlusion. Blood 121: 546-555, 2013. IF: 9.898 (*equivalent place). P80. Connes P and Coates TD. Autonomic nervous system dysfunction: implication in sickle cell disease. CR Biologie336: 142-147, 2013. IF: 1.533 P81. Connes P, Simmonds MJ, Brun JF and Baskurt OK. Exercise hemorheology: classical data, recent findings and unresolved issue. Clin Hemorheol Microcirc53: 187-199, 2013. IF: 3.398 P82. Lemaire C, Lamarre Y, Lemonne N, Waltz X, Chahed S, Cabot F, Botez I, Tressieres B, Lalanne-Mistrih ML, Etienne-Julan M and Connes P. Severe proliferative retinopathy is associated with blood hyperviscosity in sickle cell hemoglobin-C disease but not in sickle cell anemia. Clin Hemorheol Microcirc55: 205-212, 2013. IF: 3.398 P83. Lemonne N, Lamarre Y, Romana M, Mukisi-Mukaza M, Hardy-Dessources MD, Tarer V, Mougenel D, Waltz X, Tressieres B, Lalanne-Mistrih ML, Etienne-Julan M, Connes P. Does increased red blood cell deformability raises the risk for osteonecrosis in sickle cell anemia? Blood 121: 3054-3056, 2013. IF: 9.898 P84. Connes P, Verlhac S, Bernaudin F. Advances in understanding the pathogenesis of cerebrovascular vasculopathy in sickle cell anaemia. Br J Haematol 161: 484-498, 2013. IF: 4.941 P85. Waltz X, Romana M, Hardy-Dessources MD, Lamarre Y, Divialle-Doumdo L, Petras M, Tarer V, Tressieres B, Lalanne-Mistrih ML, Maillard F, Hierso R, Baltyde KC, Hue O, Etienne-Julan M, Connes P. Hematological and hemorheological determinants of the six-minute-walk test performance in children with sickle cell anemia. Plos One 8: e77830, 2013. IF: 4.092 P86. Connes P, Lamarre Y, Hardy-Dessources MD, Lemonne N, Waltz X, Mougenel D, Mukisi-Mukasa M, Lalanne-Mistrih ML, Tarer V, Tressieres B, Etienne-Julan M, Romana M. Decreased hematocrit-to-viscosity ratio and increased lactate dehydrogenase level in patients with sickle cell anemia and recurrent leg ulcers. Plos One 8: e79680, 2013. IF: 4.092 P87. Diaw M, Connes P, Samb A, Sow AK, Sall ND, Sar FB, Ba A, Diop S, Niang MN, Tripette J. Intraday blood rheological changes induced by Ramadan fasting in sickle cell trait carriers. Chronobiol Int 30:1116-1122, 2013. IF: 4.02 P88. Tripette J, Hardy-Dessources MD, Romana M, Hue O, Diaw M, Samb A, Diop S, Connes P. Exercise-related complications in sickle cell trait. Clin Hemorheol Microcirc 55: 29-37, 2013. IF: 3.398 P89. Lamarre Y, Lalanne-Mistrih ML, Romana M, Lemonne N, Mougenel D, Waltz X, Tressieres B, Etienne-Julan M, Tarer V, Hardy-Dessources MD, Connes P. Male gender, increased blood viscosity, body mass index and triglyceride levels are independently associated with systemic relative hypertension in sickle cell anemia. Plos One 13;8(6):e66004, 2013. IF: 4.092 P90. Connes P, Harmon KG, Bergeron MF. Pathophysiology of exertional death associated with sickle cell trait: can we make a parallel with vaso-occlusion mechanisms in sickle cell disease? Br J Sports Med 47: 190, 2013. IF: 4.144 P91. Bogui P, Balayssac-Siransy E, Connes P, Nalourgo T, Ouattara S, Pichon A, Dah C. The PhysioFlow thoracic impedancemeter is not valid for the measurements of cardiac hemodynamic parameters in chronic anemic patients. Plos One 8: e79086, 2013. IF: 4.092 P92. Waltz X, Romana M, Lalanne-Mistrih ML, Machado RF, Lamarre Y, Tarer V, Hardy-Dessources MD, Tressieres B, Divialle-Doumdo L, Petras M, Maillard F, Etienne-Julan M, Connes P. Hematological and hemorheological determinants of resting and exercise-induced hypoxemia in children with sickle cell disease. Haematologica 98:1039-1044, 2013. IF: 6.424 P93. Simmonds MJ, Connes P, Sabapathy S. Exercise-induced blood lactate increase does not change red blood cell deformability in cyclists. Plos One 8:e71219, 2013. IF: 4.092 P94. Diaw M, Samb A, Diop S, Sall ND, Ba A, Cisse F, Connes P. Effects of hydration and water deprivation on blood viscosity during a soccer game in sickle cell trait carriers. Br J Sports Med 48: 326-331, 2014. IF: 4.144 P95. Pichon A, Lamarre Y, Voituron N, Marchant D, Vilar J, Richalet JP and Connes P. Red blood cell deformability is very slightly decreased in erythropoietin deficient mice. Clin Hemorheol Microcirc 56: 41-46, 2014. IF: 3.398 P96. Nebor D, Bowers A, Connes P, Hardy-Dessources MD, Knight-Madden J, Reid H, Cumming V, Romana M. Plasma concentration of platelet-derived microparticles is related to painful vaso-occlusive phenotype severity. Plos One 9: e87243, 2014. IF: 4.092 P97. Connes P, Lamarre Y, Waltz X, Ballas SK, Lemonne N, Etienne-Julan M, Hue O, Hardy-Dessources MD, Romana M. Hemolysis and abnormal hemorheology in sickle cell anemia. Br J Haematol 165: 564-572, 2014. IF: 4.941 P98. Faes C, Balayssac-Siransy E, Connes P, Hivert L, Danho C, Bogui P, Martin C, Pialoux V. Moderate endurance exercise in patients with sickle cell anemia: effects on oxidative stress and endothelial activation. Br J Haematol 164: 124-130, 2014. IF: 4.941 P99. Hardeman M, Alexy T, Brouwer B, Connes P, Jung F, Kuipers H, Baskurt OK. EPO or PlacEPO? Science versus practical experience Biorheology 51: 83-90, 2014. IF: 1.93 P100. Hedreville M, Charlot K, Waltz X, Sinnapah S, Lemonne N, Etienne-Julan M, Soter V, Hue O, Hardy-Dessources MD, Barthelemy JC, Connes P. Acute moderate exercise does not further alter the autonomous nervous activity in patients with sickle cell anemia. Plos One 9: e95563, 2014. IF: 4.092 P101. Hierso R, Waltz X, Mora P, Romana M, Lemonne N, Connes P*, Hardy-Dessources MD*. Effects of oxidative stress on red blood cell rheology in sickle cell patients. Br J Haematol 166: 601-606, 2014. IF: 4.941 (*equivalent place). P102. Lamarre Y, Romana M, Lemonne N, Hardy-Dessources MD, Tarer V, Mougenel D, Waltz X, Tressieres B, Lalanne-Mistrih ML, Etienne-Julan M, Connes P. Alpha thalassemia protects sickle cell anemia patients from macro-albuminuria through its effects on red blood cell rheological properties. Clin Hemorheol Microcirc 57: 63-72, 2014. IF: 3.398 P103. Lemonne N, Lamarre Y, Romana M, Hardy-Dessources MD, Lionnet F, Waltz X, Tarer V, Mougenel D, Tressieres B, Lalanne-Mistrih ML, Etienne-Julan M, Connes P. Impaired blood rheology plays a role in chronic disorders in sickle cell-hemoglobin C disease. Haematologica 99: 74-75, 2014. IF: 6.424 P104. Lemonne N, Romana M, Lamarre Y, Hardy-Dessources MD, Lionnet F, Waltz X, Tarer V, Mougenel D, Tressieres B, Lalanne-Mistrih ML, Etienne-Julan M, Connes P. Association between relative systemic hypertension and otologic disorders in patients with sickle cell-hemoglobin C disorder. Am J Hematol 89: 667, 2014. IF: 4.671 P105. Simmonds MJ, Detterich J, Connes P. Nitric oxide, vasodilation and red blood cell. Biorheology 51: 121-134, 2014. IF: 1.93 P106. Waltz X, Baillot M, Connes P, Bocage B, Renaudeau D. Effects of hydration level and heat stress on thermoregulatory responses, hematological and blood rheological properties in growing pigs. PLoS One 9: e102537, 2014. IF: 4.092 P107. Waltz X, Baillot M, Connes P, Gourdine JL, Philibert L, Beltan E, Chalabi T, Renaudeau D. Effects of genotype and heat stress on the blood rheology of pigs. Clin Hemorheol Microcirc In press. IF: 3.398 P108. Sinnapah S, Cadelis G, Waltz X, Lamarre Y and Connes P. Overweight explains the increased red blood cell aggregation in patients with obstructive sleep apnea. Clin Hemorheol Microcirc In press. IF: 3.398 P109. Lamarre Y, Hardy-Dessources MD, Romana M, Lalanne-Mistrih ML, Waltz X, Petras M, Doumdo L, Blanchet-Deverly A, Martino J, Tressieres B, Maillard F, Tarer V, Etienne-Julan M and Connes P. Relationships between systemic vascular resistance, blood rheology and nitric oxide in children with sickle cell anemia or sickle cell-hemoglobin C disease. Clin Hemorheol Microcirc In press. IF: 3.398 P110. Vent-Schmidt J, Waltz X, Pichon A, Hardy-Dessources MD, Romana M, Connes P. Indirect viscosimetric method is less accurate than ektacytometry for the measurement of red blood cell deformability. Clin Hemorheol Microcirc In press. IF: 3.398 P111. Waltz X, Hardy-Dessources MD, Lemonne N, Mougenel D, Lalanne-Mistrih ML, Lamarre Y, Tarer V, Tressieres B, Etienne-Julan M, Hue O, Connes P. Is there a relationship between the hematocrit-to-viscosity ratio and microvascular oxygenation in brain and muscle? Clin Hemorheol Microcirc In press. IF: 3.398 P112. Diaw M, Diop S, Wennonga FY, Seck M, Faye BF, Niang MN, Samb A, Connes P. Blood viscosity is lower in trained than in sedentary sickle cell trait carriers. Clin Hemorheol Microcirc In press. IF: 3.398 P113. Charlot K, Waltz X, Hedreville M, Sinnapah S, Lemonne N, Etienne-Julan M, Soter V, Hue O, Hardy-Dessources MD, Connes P. Impaired oxygen uptake efficiency slope and off-transient kinetics of pulmonary oxygen uptake in sickle cell anemia are associated with hemorheological abnormalities Clin Hemorheol Microcirc In press. IF: 3.398 P114. Grau M, Mozar A, Charlot K, Lamarre Y, Weyel L, Suhr F, Collins B, Jumet S, Hardy-Dessources MD, Romana M, Lemonne N, Etienne-Julan M, Antoine-Jonville S, Bloch W, Connes P. High red blood cell nitric oxide synthase activation is not associated with improved vascular function and red blood cell deformability in sickle cell anemia. Br J Haematol In press. IF: 4.941 P115. Lemonne N, Billaud M, Waltz X, Romana M, Hierso R, Etienne-Julan M, Connes P. Rheology of red blood cells in patients with HbC disease. Clin Hemorheol Microcirc In press. IF: 3.398 P116. Chalencon S, Pichot V, Roche F, Lacour JR, Garet M, Connes P, Barthelemy JC, Busso T. Modeling of performance and ANS activity for predicting future responses to training. Eur J Appl Physiol In press. IF: 2.147 P117. Mozar A, Grau M, Lamarre Y, Weyel L, Suhr F, Collins B, Hardy-Dessources MD, Romana M, Lemonne N, Etienne-Julan M, Bloch W, Connes P. Red blood cell nitric oxide synthase activation is increased in patients with sickle cell hemoglobin C disease. Am J Hematol In press. IF: 4.671 P118. Faes C, Charrin E, Connes P, Pialoux V, Martin C. Effects of physical activity in transgenic SAD mice on haematological and haemorheologic parameters. Am J Hematol In press. IF: 4.671 P119. Vent-Schmidt J, Waltz X, Romana M, Hardy-Dessources MD, Lemonne N, Billaud M, Etienne-Julan M, Connes P. Blood thixotropy in patients with sickle cell anemia: role of hematocrit and red blood cell rheological properties. Plos One In press. IF: 4.092 P120. Caillaud C, Connes P, Ben-Saad H, Mercier J. Erythropoietin enhances total lipid oxidation during prolonged exercise in humans. J Physio Biochem In press. IF: 2.496 P121. Connes P. Obstructive sleep apnea and sickle cell disease: towards hemorheological abnormalities and vascular dysfunction worsening. Sleep Med Rev In press. IF: 9.141 P122. Key NS, Connes P, Derebail VK. Negative Health Implications Of Sickle Cell Trait in High Income Countries: From The Football Field To The Laboratory. Br J Haematol In press. IF: 4.941 P123. Joly P, Garnier N, Kebaili K, Griffon-Renoux C, Dony A, Cheikh N, Renard C, Ceraulo A, Cuzzubbo D, Pondarré C, Martin C, Pialoux V, Francina A, Bertrand Y, Connes P. G6PD deficiency and absence of α-thalassaemia increase the risk for cerebral vasculopathy in children with sickle cell anaemia. Eur J Haematol In press. IF: 2.41 P124. Charlot K, Möeckesche B, Jumet S, Romana M, Waltz X, Divialle-Doumdo L, Hardy-Dessources MD, Petras M, Tressieres B, Pichon A, Tarer V, Hue O, Etienne-Julan M, Antoine-Jonville S, Connes P. Physical activity level is not a determinant of autonomic nervous system activity and clinical severity in children/adolescents with sickle cell anemia. Pediatr Blood Cancer In press. IF: 2.56 P125. Connes P. Is there a link between sickle cell trait, exercise-related rhabdomyolysis and compartment syndrome? Lancet In press. IF: 39.21 P126. Ferdinand S, Connes P, Brudey L, Cita KC, Tressieres B, Lemonne N, Hardy-Dessources MD, Lamarre Y, Waltz X, Etienne-Julan M, Romana M. Impact of eNOS polymorphisms on red blood cell aggregation in sickle cell disease. Blood Cells Mol Dis In press. IF: 2.33 P127. Mozar A, Charlot K, Sandor B, Rabai M, Lemonne N, Billaud M, Hardy-Dessources MD, Beltan E, Pandey RC, Connes P*, Ballas SK*. Pfaffia Paniculata extract improves red blood cell deformability in sickle cell patients. Clin Hemorheol Microcirc In press (*equivalent place). IF: 2.22 P128. Lemonne N, Charlot K, Waltz X, Ballas SK, Lamarre Y, Lee K, Hierso R, Connes C, Etienne-Julan M, Romana M, Connes P. Hydroxyurea treatment does not increase blood viscosity and improves red blood cell rheology. Haematologica In press. IF: 5.814 P129. Renoux C, Parrow N, Faes C, Joly P, Hardeman M, Tisdale J, Levine M, Garnier N, Bertrand Y, Kebaili K, Cuzzubbo D, Cannas G, Martin C, Connes P. Importance of methodological standardization for the ektacytometric measures of red blood cell deformability in sickle cell anemia. Clin Hemorheol Microcirc In press. IF: 2.24 P130. Diaw M, Pialoux V, Martin C, Samb A, Diop S, Faes C, Mury P, Sall ND, Diop SN, Ranque B, Mbaye MN, Gueye MD, Key NS, Connes P. Sickle cell trait worsens oxidative stress, abnormal blood rheology and vascular dysfunction in type 2 diabetes. Diabetes Care In press. IF: 8.42 P131. Connes P, Alexy T, Detterich J, Romana M, Hardy-Dessources MD, Ballas SK. The role of blood rheology in sickle cell disease. Blood Rev In press. IF: 5.57

Articles nationaux

PN1. Connes P and Caillaud C. Influence de l'érythropoïétine sur le globule rouge et le métabolisme oxydatif. Rev Fr Lab 350: 61-66, 2003. PN2. Debaud J, Martin C, Monchanin G, Perrey S, Sara F, Thiriet P, Massarelli R, Hue O and Connes P. Métabolisme énergétique et performance sportive chez les porteurs du trait drépanocytaire : peut-on parler d'intolérance à l'effort ? Revue STAPS 74: 23-39, 2006. PN3. Brun JF, Connes P and Varlet-Marie E. Alterations of blood rheology during and after exercise are both consequences and modifiers of body's adaptation to muscular activity. Sc Sports, 22: 251-266, 2007. PN4. Connes P, Perrey S, Sara F, Hardy-Dessources, Hedreville M and Hue O. Lactate Removal Ability and VO2 . Recovery Kinetics in Sickle Cell Trait Carriers Compared with Normal Haemoglobin Subjects: Preliminary Data. The Open Journal of Sports medicine, 49-54, 2009. PN5. Connes P and Boisseau M. Hémorhéologie. Sang Thrombose et Vaisseaux 22: 126-136, 2010. PN6. Connes P. Hémoglobinopathies et sport : est-ce qu’il existe des risques ? Cardio & Sport 36 : 31-33, 2013. PN7. Waltz X and Connes P. Pathophysiology and physical activity in patients with sickle cell anemia. Movement and Sport Sciences (Sciences et Motricité), In press. PN8. Connes P. Hémorhéologie et exercice. Cardio & Sport, In press. PN9. Connes P. Coagulation et exercice. Cardio & Sport, In press. PN10. Connes P. Agrégation plaquettaire et exercice. Cardio & Sport, In press. PN11. Connes P. Hématies et exercice : Physiologie et Physiopathologie Nutrition et Endocrinologie, In press.      

Chapitres d'ouvrages collectifs

C1. Connes P, Beltan E, Chalabi T and Tripette J. Effects of exercise on blood coagulation activity in sickle cell trait carriers: abnormalities or not? In: Handbook of Hematology Research - Blood Coagulation: Hemorheology, Hemophilia and Blood Coagulation(Edition: Nova Science Publishers), 2009. ISBN: 978-1-60741-619-7 https://www.novapublishers.com/catalog/product_info.php?cPath=23_29&products_id=10077&osCsid=e6e9f 0122aba1b1cc12df996f2f2f51a   C2. Connes P, M Boisseau and Vicaut E. Hémorhéologie et microcirculation. In: Traité de Médecine Vasculaire – Tome 1 (Editeur : Elsevier Masson), 2010. http://www.elsevier-masson.fr/traite-de-medecine-vasculaire-tome-1-p-7051.html   C3. Connes P. Sickle cell trait. In: Encyclopedia of Exercise Medicine in Health and Disease (Editors: FC Mooren, JS Skinner - Edition: Springer), 2012. http://www.springer.com/medicine/book/978-3-540-36065-0   C4. Connes P. Hemorheology and exercise. In: Encyclopedia of Exercise Medicine in Health and Disease (Editors: FC Mooren, JS Skinner - Edition: Springer), 2012. http://www.springer.com/medicine/book/978-3-540-36065-0 C5. Connes P, Dufour S, Pichon A and Favret F. Blood Rheology, Blood Flow and Human Health.In : Nutrition and Enhanced Sports Performance: Recommendations for Muscle Building (Editors : Debasis Bagchi, Sreejayan Nair and Chandan K. Sen – Edition : Elsevier), 2013 (In press).

Vulgarisation Scientifique

V1. Connes P and Driss F. Conseils destinés aux porteurs du trait drépanocytaire lors d’une pratique sportive. In: Brochure sur les porteurs du trait drépanocytaires (AS), 2013 – Centre d’Information et de Dépistage de la Drépanocytose (CIDD, Paris). Coordination : R Girot. V2. ACSM and NCAA Joint Statement
Sickle Cell Trait and Exercise. http://www.ncaa.org/wps/wcm/connect/public/NCAA/Health+and+Safety/Sickle+Cell/Resources/ACSM+and+NCAA+Joint+Statement+-+Sickle+Cell+Trait+and+Exercise V3. American College of Sport Medicine updated comment on « Sickle Cell Trait with Exercise and Sports », 2013 (In press).